Why choose AstraZeneca Spain?
AstraZeneca Spain is a rising force in our global business. With headquarters in Madrid and our global hub in Barcelona, we’ve become an important international centre of excellence in the fight against critical disease. Boasting vibrant universities and business schools, the Barcelona ecosystem is a place where scientists can thrive. We attract a diverse workforce from across the globe, shining a beacon for innovation in a country that’s committed to clinical development.
We invite you to bring your talents to Barcelona where our respiratory medicine R&D and Global Marketing centre offers opportunities in R&D, IT, Commercial and HR. Or join us in Madrid and shape our growth in our BUs (Respiratory, Oncology & CVRM ), and a range of Corporate functions. Additionally, you can find sales roles throughout the country. Together, we’re contributing to a world-leading pipeline of therapeutics and delivering life-changing medicines to patients.
Who do we look for?
Calling all tech innovators, ownership takers, challenge seekers and proactive collaborators. At AstraZeneca Spain, breakthroughs born in the lab become transformative medicine for the world's most complex diseases. Alongside technical expertise, colleagues have the resilience, energy and collaborative mindset to change lanes, work with different teams and start projects from scratch.
Here, diverse minds and bold disruptors can meaningfully impact the future of healthcare using cutting-edge technology. Whether you join us in Madrid or Barcelona, you can make a tangible impact within a global biopharmaceutical company that invests in your future. Join a talented global team that's powering AstraZeneca to better serve patients every day.
Success Profile
Ready to make an impact in your career? If you're passionate, growth-orientated and a true team player, we'll help you succeed. Here are some of the skills and capabilities we look for.
Diverse collaborators
This is a speak-up culture that values collaboration. You’ll proactively bring your unique perspectives, experiences and skills to the table and seek the same from others. With our international team composition and the need for fast-paced collaboration, you’ll always be building new connections with colleagues.
Cutting-edge innovators
When you join us, you’ll be part of a team that embraces digital technology and data to transform the way we work and the work we do. Every day, you’ll help make history, empowered to ignite your creativity and build something enduring.
Resilient trailblazers
Here, the answers aren’t always available. So, you’ll need to bring a fearless, self-starter mindset to navigate uncharted territories. You’ll harness your ceaseless energy to discover and make the necessary connections with colleagues to shape the future and achieve maximum impact.
Agile movers
Seize ownership and excel with autonomy to enjoy the constant rush of ground-breaking discovery. Your ability to anticipate sudden shifts and adapt swiftly will prove critical as you make your mark in an environment that rewards initiative and resilience.
Responsibilities
Role Overview
A senior engineering leadership role responsible for the technical direction, hands-on delivery, and production scaling of AI solutions across enterprise enabling functions — including HR, Finance, Procurement, Legal, Audit, Compliance, and Business Development.
This is a builder-leader role. The Engineering Director combines deep hands-on AI engineering — designing and shipping multi-agent systems, RAG pipelines, and governed AI applications — with the technical leadership required to drive a team from opportunity identification through to production deployment. They bring a rare and deliberate combination: the ability to move from idea to working proof-of-concept in days, alongside significant depth in AI governance, operational resilience, and regulatory compliance — not as adjacent knowledge, but as a core professional discipline that shapes how they build, assess, and operate AI systems.
The role sits within the Enterprise AI function and works in close partnership with enterprise technology, data engineering, technology governance, legal, information security, and functional stakeholders to deliver AI that is production-grade, auditable, and compliant from the first commit — not retrofitted at the end. Given geographic considerations, the role carries particular responsibility for navigating multi-jurisdictional data sovereignty, regulatory divergence, and cross-border AI governance — ensuring systems are defensible under all applicable regulatory regimes.
Context
Enabling functions — HR, Finance, Procurement, Legal, Audit, and Compliance — govern how an organisation hires, contracts, spends, reports, partners, audits, and maintains compliance. They represent high-value AI opportunities and high-consequence environments — where outputs carry regulatory, financial, and reputational weight. Realising value at scale requires engineering leadership that can navigate complex data landscapes, build for reuse, and embed governance, human oversight, and operational resilience into architecture decisions from the outset.
These AI applications do not exist in a vacuum. Each system must be governed — classified, registered, monitored, auditable, and defensible to regulators, auditors, and internal oversight functions. The governance and resilience challenge is twofold: building AI systems that are themselves resilient and well-governed, and ensuring the frameworks, processes, and controls that surround those systems are robust, proportionate, and continuously maintained. The role demands someone who has operated at this intersection for a significant portion of their career — not someone encountering governance as a new discipline.
This role is designed for an engineer who has already built AI applications inside a large, regulated enterprise, who has demonstrated experience delivering AI solutions across multiple enabling functions (e.g., HR, Finance, Procurement, Legal, Audit), who has significant experience governing AI systems and embedding operational resilience disciplines around them, and who treats regulatory requirements as architecture decisions — not compliance checkboxes.
Key Responsibilities
1. Technical Direction & Architecture
- Lead the engineering roadmap for AI across enabling functions, aligning architecture, delivery sequencing, and capability development to business priorities across HR, Finance, Procurement, Legal, Audit, and Compliance
- Set architectural direction for scalable, governed AI platforms — designing for modularity, cross-functional reuse, and compliance from the outset
- Make high-consequence technical decisions on architecture, build-vs-buy, model strategy (foundation models, fine-tuning, multi-provider orchestration, RAG), and integration patterns
- Drive platform thinking over project thinking — building shared components, reusable agent patterns, and common governance instrumentation that accelerate delivery across the portfolio
- Ensure architecture accounts for data sovereignty requirements — model routing, data residency, and hosting decisions that respect jurisdictional boundaries and cross-border transfer requirements
- Shape investment cases for senior stakeholders, articulating engineering decisions in terms of scalability, risk, regulatory defensibility, and value creation
2. Hands-On AI Engineering & Delivery
- Design and ship multi-agent LLM architectures across multiple model providers, choosing models against product requirements and compliance constraints — including sovereignty-aware routing through region-specific infrastructure where required
- Build RAG pipelines over real enterprise corpora with named single-purpose agents, hallucination guards before any user-facing output, and immutable audit logging at every stage
- Use AI-assisted development tooling to compress delivery from months to days, while keeping architecture decisions, model routing, and guardrails under deliberate human control
- Lead technical design for complex solutions spanning enabling functions — HR policy automation, contract risk scoring, procurement analytics, compliance monitoring, financial forecasting, audit analytics, and document intelligence — with governance built in from the first build
- Ensure rapid experimentation capability with clear engineering gates between proof-of-concept, pilot, and production — measuring against real data and real success criteria, not mock demos
3. AI Governance & Regulatory Compliance
This is a defining pillar of the role. The organisation requires an engineering leader with significant, demonstrated experience in AI governance — someone who has designed governance frameworks, built governance tooling, and operated in governance roles — not simply complied with governance requirements set by others.
- Governance architecture: Design and operate the governance structures that surround AI applications — classification and tiering, risk assessment, model registration, approval workflows, ongoing monitoring obligations, and decommissioning criteria
- Regulatory compliance (multi-jurisdictional): Ensure systems meet requirements under applicable data protection laws, AI-specific regulations (e.g., EU AI Act risk classification, emerging national AI frameworks), and sector-specific operational resilience expectations — navigating divergence and maintaining defensibility under multiple regimes
- Data sovereignty: Design data-residency and model-routing approaches that respect adequacy arrangements, data-transfer mechanisms, and sovereignty constraints — ensuring processing is appropriately separated by jurisdiction where required, with sovereign model options (e.g., region-specific cloud deployments, local model hosting)
- Responsible agentic architecture: Design systems where AI agents reason autonomously but consequential action is human-gated — with every decision writing an audit row recording what model decided what, on what evidence
- Governance-by-design: Embed deterministic classification/routing layers, human-in-the-loop oversight, model/data cards, and full audit trails into standard engineering practice — treating these as first-class architecture components, not afterthoughts
- Second-line posture: Ensure governance tooling supports independent review — maintaining separation between the teams that build and the functions that assess, with tool design reflecting this control
- Domain-specific requirements: Ensure AI systems handling financially material data (Finance), legally privileged documents (Legal), employee-sensitive information (HR), supplier-confidential data (Procurement), or audit evidence (Audit) meet the specific governance and evidential standards those domains require (e.g., SOX, legal privilege, chain-of-custody, employment law)
- Lifecycle governance: Own the ongoing governance obligations for live AI systems — periodic re-assessment, performance review against stated tolerances, change-impact assessment, and documented decision trails for model updates or retirement
4. Operational Resilience — For AI Systems
The second defining pillar. The role requires significant experience in operational resilience as a discipline — not just awareness, but hands-on engineering delivery.
- Engineer operational resilience into AI applications — circuit breakers, provider fallbacks, graceful degradation, fail-safe defaults, and dependency-aware architecture so essential functions survive outages
- Design for failure: assume model providers, data sources, and integration points will fail, and ensure user-facing services degrade safely rather than catastrophically
- Ensure AI systems are mapped against the organisation's important business services framework — with defined impact tolerances, recovery objectives, and tested failover paths
5. Engineering Leadership & Team Development
- Lead a multi-disciplinary engineering team comprising software, ML, data, and platform engineers — recruiting, developing, and retaining strong technical talent
- Set engineering culture and standards for code quality, testing, documentation, peer review, and production readiness
- Develop senior technical contributors and engineering leads — building depth and succession within the team
- Mentor and enable non-technical colleagues across enabling functions to ship their own AI applications, building AI literacy across HR, Finance, Procurement, Legal, Audit, and Compliance
- Manage capacity and team topology — making deliberate choices about structure, specialisation, and balance across discovery, delivery, and sustainment
6. Delivery & Production Excellence
- Drive end-to-end engineering delivery from architecture through to production deployment, scaling, monitoring, and lifecycle management
- Partner with enterprise technology teams to leverage shared platforms, infrastructure, and services — ensuring solutions are built on common foundations and contribute back to enterprise capability
- Establish and enforce standards for model serving, data pipelines, API design, integration patterns, security, and observability
- Drive MLOps maturity including CI/CD, automated testing, performance monitoring, incident management, and capacity planning
- Own the data engineering approach for AI across enabling functions — pipelines, feature stores, and data products designed for quality, governance, and reuse
- Establish data quality, lineage, and governance standards appropriate for financially material data, legally privileged documents, employee PII, and personally identifiable information subject to applicable data protection laws
7. Model Quality, Drift & Assurance
- Establish model-drift and bias monitoring across the portfolio — measuring divergence across runs and generating targeted refinement recommendations
- Design and operate AI red-team capability to probe and refine model outputs before release and on an ongoing basis
- Build automated fairness testing, explainability pipelines, and decision audit trails embedded in standard workflows
- Own technical risk management across the portfolio including model degradation, data quality drift, dependency risk, and integration risk
- Ensure model assurance reporting meets the expectations of internal audit, technology governance, and external regulators
8. Scaling Through Partnership
- Work in close partnership with enterprise technology to align on shared infrastructure, platform services, tooling, and engineering standards
- Identify and scale opportunities across enabling functions — recognising where a solution proven in one function (e.g., contract intelligence in Legal) can be adapted and deployed in another (e.g., supplier risk in Procurement)
- Engage external technology partners strategically — co-developing or integrating capabilities where they accelerate delivery or provide specialist functionality
- Shape joint programmes with partners, defining technical scope, integration architecture, and quality standards — ensuring partnerships deliver production-grade outcomes
- Build a scaling model that leverages shared services, external partners, and cross-functional reuse to multiply impact without proportional headcount growth
9. Stakeholder Partnership & Adoption
- Serve as a credible technical partner to functional leaders across HR, Finance, Procurement, Legal, Audit, and Compliance — providing counsel on AI opportunity, risk, regulatory posture, and investment
- Work as an internal consultant: run discovery with each business unit, surface real problems, frame concrete use cases with measurable success criteria, and drive adoption through continuous UX iteration and direct user-feedback loops
- Translate between engineering complexity and business strategy — communicating trade-offs, timelines, and constraints so leaders can make informed decisions
- Measure success by real adoption and operational impact, not by demonstrations — building KPI/KRI frameworks giving leaders visibility into usage, quality, and value
10. Enterprise AI Integration
- Represent enabling functions within enterprise AI leadership forums and architecture governance, ensuring alignment on standards, platform strategy, and shared services
- Contribute to enterprise AI governance including architecture review boards, AI policy development, and standards evolution
- Drive reuse and knowledge sharing — identifying where governance and resilience patterns developed for enabling functions can accelerate delivery elsewhere
- Advocate for enabling function requirements within the broader enterprise technology agenda, ensuring platform priorities reflect the needs of regulated, process-critical functions
Date Posted
04-sept-2026Closing Date
18-sept-2026AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.
Reasons to Join
Thomas Mathisen
There are many things I enjoy when working at AstraZeneca, mainly the Speak up culture, the great colleagues that are in my teams, the great products that AstraZeneca provides to our patients and the challenging conversations I have around our medicines.
Christine Recchio
Working at AstraZeneca has impacted my life in such a positive way. I now have an improved work-life balance through creating my own schedule and time management, I feel a balance that I didn’t have before.
Stephanie Ling
There are a lot of reasons why I enjoy working in AstraZeneca, my colleagues being one of them. My team members and the managers have provided a great deal of guidance in helping me to be more confident in my daily work.
What we offer
We're driven by our shared values of serving people, society and the planet. Our people make this possible, which is why we prioritise diversity, inclusivity, balance and sustainability. Discover what a career at AstraZeneca could mean for you.
An award-winning company
We're passionate about being a great place to work, and 84% of our employees would recommend us as an employer. We've been recognised as a Top Employer in Spain, an EFR Family Responsible Business, and we achieved third place in Forbes Spain's Top 50 Best Places to Work list.
Inclusive environment
Diversity and inclusion are embedded in everything we do, and our different views, experiences and strengths enrich our culture. There's no salary gap at AstraZeneca, and the number of female employees has increased by four per cent over the last three years. We've also made all positions fully accessible.
Work-life balance
Your wellbeing means a lot to us, and we're here to support you through all of life's ups and downs. That's why we offer an unpaid leave policy, annual leave, reduced-hours timetables and a host of benefits, including a retirement plan, long service award, and health and travel insurance.
Sustainability initiatives
We're committed to harnessing the power of science to become a more sustainable business. We've reduced our carbon footprint by over 9,000 kg of CO2 over the last two years, and we lead the European GoGreen Project, which aims to introduce environmentally friendly options in our fleet of corporate vehicles.
Join our Talent Network
Be the first to receive job updates and news from AstraZeneca
Sign up